 |
Действенное лечение Раковых заболеваний |
|
|||||
|
 |
||||||
 AbstractRotational Field Quantum Magnetic Resonance (RFQMR) is a technology that is made to deliver highly complex quantum electromagnetic beams in the sub-radio and near-radio frequency spectrum. The beams can be precisely controlled and focused onto tissues therein generating streaming voltage potentials. In osteoarthritis, this flow in the joint causes forced movement of hydrogen protons in the extra cellular matrix (ECM) due to the alteration in QMR spin in the hydrogen atoms and stimulates the chondrocytes. Thirty-five patients of osteoarthritis were treated with RFQMR focused on both knees for one hour every day for 21 days. They were evaluated before, immediately post treatment and one month after treatment with the Knee Society Scoring System and dynamometry. There was highly significant improvement in Pain Score, Total Knee Score, Total Functional Score, Range of Movement and force of extension, immediately after the treatment vis-a-vis pre treatment values and this improvement persisted when evaluation was repeated after one month. RFQMR is an effective method of treatment of osteoarthritis of the knee joint. Прочесть работу полностью Effects of pulsed electromagnetic fields on articular hyaline cartilage: review of experimental and clinical studies  AbstractOsteoarthritis (OA) is the most common disorder of the musculoskeletal system and is a consequence of mechanical and biological events that destabilize tissue homeostasis in articular joints. Controlling chondrocyte death and apoptosis, function, response to anabolic and catabolic stimuli, matrix synthesis or degradation and inflammation is the most important target of potential chondroprotective treatment, aimed to retard or stabilize the progression of OA. Although many drugs or substances have been recently introduced for the treatment of OA, the majority of them relieve pain and increase function, but do not modify the complex pathological processes that occur in these tissues. Pulsed electromagnetic fields (PEMFs) have a number of well-documented physiological effects on cells and tissues including the upregulation of gene expression of members of the transforming growth factor b super family, the increase in glycosaminoglycan levels, and an antiinflammatory action. Therefore, there is a strong rationale supporting the in vivo use of biophysical stimulation with PEMFs for the treatment of OA. In the present paper some recent experimental in vitro and in vivo data on the effect of PEMFs on articular cartilage were reviewed. These data strongly support the clinical use of PEMFs in OA patients. Прочесть работу полностью Modification of osteoarthritis by pulsed electromagnetic field—a morphological study  Summary Objective: Hartley guinea pigs spontaneously develop arthritis that bears morphological, biochemical, and immunohistochemical similarities to human osteoarthritis. It is characterized by the appearance of superficial fibrillation by 12 months of age and severe cartilage lesions and eburnation by 18 months of age. This study examines the effect of treatment with a pulsed electromagnetic field (PEMF) upon the morphological progression of osteoarthritis in this animal model. Design: Hartley guinea pigs were exposed to a specific PEMF for 1 h/day for 6 months, beginning at 12 months of age. Control animals were treated identically, but without PEMF exposure. Tibial articular cartilage was examined with histological / histochemical grading of the severity of arthritis, by immunohistochemistry for cartilage neoepitopes, 3B3(−) and BC-13, reflecting enzymatic cleavage of aggrecan, and by immunoreactivity to collagenase (MMP-13) and stromelysin (MMP-3). Immunoreactivity to TGFβ, interleukin (IL)-1β, and IL receptor antagonist protein (IRAP) antibodies was examined to suggest possible mechanisms of PEMF activity. Results: PEMF treatment preserves the morphology of articular cartilage and retards the development of osteoarthritic lesions. This observation is supported by a reduction in the cartilage neoepitopes, 3B3(−) and BC-13, and suppression of the matrix-degrading enzymes,collagenase and stromelysin. Cells immunopositive to IL-1 are decreased in number, while IRAP-positive cells are increased in response totreatment. PEMF treatment markedly increases the number of cells immunopositive to TGFβ. Conclusions: Treatment with PEMF appears to be disease-modifying in this model of osteoarthritis. Since TGFβ is believed to upregulate gene expression for aggrecan, downregulate matrix metalloprotease and IL-1 activity, and upregulate inhibitors of matrix metalloprotease,the stimulation of TGFβ may be a mechanism through which PEMF favorably affects cartilage homeostasis. Прочесть работу полностью Proteoglycan synthesis in bovine articular cartilage explants exposed to different low-frequency low-energy pulsed electromagnetic fields  Summary Objective: To investigate the role of pulsed electromagnetic field (PEMF) exposure parameters (exposure length, magnetic field peak amplitude, pulse frequency) in the regulation of proteoglycan (PG) synthesis of bovine articular cartilage explants. Methods: Bovine articular cartilage explants were exposed to a PEMF (75 Hz; 2 mT) for different time periods: 1, 4, 9, 24 h. Then, cartilageexplants were exposed for 24 h to PEMFs of different magnetic field peak amplitudes (0.5, 1, 1.5, 2 mT) and different frequencies (2, 37, 75, 110 Hz). PG synthesis of control and exposed explants was determined by Na2-35SO4 incorporation. Results: PEMF exposure significantly increased PG synthesis ranging from 12% at 4 h to 17% at 24 h of exposure. At all the magnetic field peak amplitude values, a significant PG synthesis increase was measured in PEMF-exposed explants compared to controls, with maximal effect at 1.5 mT. No effect of pulse frequency was observed on PG synthesis stimulation. Conclusions: The results of this study show the range of exposure length, PEMF amplitude, pulse frequency which can stimulate cartilage PG synthesis, and suggest optimal exposure parameters which may be useful for cartilage repair in in vivo experiments and clinical application. Прочесть работу полностью Pulsed Electromagnetic Fields for Treating Osteo-arthritis  Summary Background: Osteo-arthritis, a painful joint disorder involving degenerative changes of the articular cartilage and subchondral bone, often results in progressive functional impairment and disability. One particular modality used by physiotherapists that shows very promising results in reducing the joint damage and pain found in osteo-arthritis is pulsed electromagnetic fields. Objective: The present objective was to examine the rationale for, and the potential efficacy of, applying pulsed electromagnetic fields for reducing joint pain and other related symptoms of osteo-arthritis. Methods The related English language literature was extensively reviewed to examine whether changes in pain might be expected from the application of pulsed electromagnetic fields to an osteo-arthritic joint, and why. Results: The basic and clinical research in this field, while somewhat limited, supports the insightful application of pulsed electromagnetic fields to ameliorate pain and disability due to osteo-arthritis. Conclusion: Further basic and clinical research to validate the use of pulsed electromagnetic fields in facilitating function and possibly in facilitating joint reparative processes in osteo-arthritis, as well the lessening of osteo-arthritic joint pain and joint dysfunction is indicated. Прочесть работу полностью |
|
 |
